Předseda
| falk@ibp.cz; mfalk@seznam.cz | |
| telefon | +420 541 517 116 (práce) +420 728 08 40 60 (mobil) |
| zaměstnavatel | Biofyzikální ústav Akademie věd ČR, v.v.i. |
| funkční zařazení | vedoucí Oddělení buněčné biologie a radiobiologie |
| adresa pracoviště | Královopolská 135612 65 Brno |
Afiliace
Institute of Biophysics of the CAS, v.v.i., Královopolská 135, 612 65 Brno, CR
Head, Department of Cell Biology and Radiobiology
Head, Laboratory of Chromatin Function, Damage and Repair
President of Radiobiological Society for Crisis Planning of the Czech Medical Society of JE Purkyně
ORCID: https://orcid.org/0000-0002-9229-0468
Scopus Author ID: 7101733680
Loop profile: 296015
Researcher ID: D-2394-2013
Oblasti vědeckého zájmu
Radiobiology: ● Radiation Protection ● Biological Effects of Different Kinds of Ionizing Radiation and the Micro- and Nanoscale; ● Mechanisms of DNA Double-Strand Break (DSB) Formation and Repair; ● Regulation of DNA Repair at the Pan-Nuclear Level and at Individual Damage Sites; ● Complex Cellular Response to Irradiation and Other Stresses; ● Mechanism of Formation of Chromosomal Aberrations; ● Mutagenesis; ● Tumor Cell Radiosensitization for Radiotherapy; ● Nanomaterials for Radiotherapy, Theranostics and Nanomedicine; ● Ion-Beam Cancer Therapy (Hadron Therapy); ● Radio-Immunotherapy; ● Hypoxia; ● Individual- and Tumor-Specific Radioresistance and Personalized Medicine; ● Radiation Exposure Biomarkers; ● Biodosimetry and Radioprotection in Civil protection and Space research
Cell & Molecular Biology: ● Chromatin Architecture and the Structure-Function Relationship; ● Higher-Order Chromatin Structure, Function and Dynamics in Regulation of Nuclear Processes and in Pathogenesis, ● Especially Carcinogenesis; ● Epigenetics; ● Genome Maintenance; ● DNA Damage, Repair and Misrepair; ● Solid Tumor and Leukemia Pathogenesis; ● Repeat Expansion Diseases (REDs)
Microscopy and Superresolution microscopy; ● (Live) Cell Imaging and Image Analysis; ● Laser Cell Micro-irradiation; ● Specimen Labelling for Microscopy; ● Methods of Cell and Molecular Biology / Biophysics.
Členství ve vědeckých radách
• Expert of the Czech Academy of Sciences for Radiobiology
• Academic Assembly of the Czech Academy of Sciences (voted member)
• Joint Program Advisory Committee of the Institute of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Rep.
• Czech Republic national delegate in the European Cooperation in Science and Technology, projects: RADAM (MP1002 CZ), Nano-IBCT (MP1002 CZ), CliniMARK (CA16113), MultiChem (CA20129)
• CANAM (Center of Accelerators and Nuclear Analytical Methods) Committee Member
Členství v dalších odborných společnostech
● Council Member of the European Radiation Research Society (ERRS)
● ERRS Councillor at the ICRR (International Association for Radiation Research)
● Gregor Mendel Genetical Society (GSGM)
● Czech Microscopic Association
● Czech Society for Cell Biology
Členství v redakčních radách
● Editor, Scientific Reports (Nature Publishing) Q1
● Editor, Frontiers in Cell and Developmental Biology (IF 5.186 / Q1)
● Frontiers in Physics (IF 5.186 / Q2)
● Editorial Board Member of Biomolecules (IF 6.064) (Q1/Q2)
● Editorial Board of ISRN Genetics
● Editorial Board of International Journal of Radiology
● Editorial Board of Journal of Biochemistry and Biophysics
Ocenění
● 2022: Cooperation Award from IBP Czech Academy of Sciences, Brno, CR
● 2021: A Prize of the European Radiation Research Society (ERRS) awarded to I. Falkova et al., 46th Annual Meeting of the ERRS (ERRS 2021), November 26th – 30, 2021, Caen, France.
● 2018: 1st Prize, The Society for Low Temperature Biology (SLTB) Meeting, 6th Sept 2018, Prague, CR (Falk M. et al. Complex description of cryopreserved cell nuclei defects by immunofluorescence microscopy: DNA lesions, chromatin decondensation, nuclear membrane ruptures; presented by M Golan).
● 2015: Young Investigators Travel Award, 15th International Congress of Radiation Research (ICRR 2015), Kyoto, Japan.
● 2009: Premium of Otto Wichterle for outstanding young scientists, Award of the Czech Academy of Sciences
● 2008: The Prize of Deutsche Gesellchaft für DNA-Reparaturforschung (DGDR), 10th Biennial Meeting of the DGDR, Berlin, Germany: Devoted for results obtained at the field of DNA repair: “Different sensitivity and response of functionally distinct chromatin domains to DSB induction”
● 2008: Second place, New England Biolabs Poster Prize, Biochemical Society Annual Symposium – DNA Damage: From Causes to Cures, December 15-17, 2008, Cambridge, Great Britain,
● 2004: The Prize of Institute of Biophysics of ASCR for excellent young scientists
● >50 invited lectures until now
Výuka
• From 2007: Masaryk University, Brno, Czech Republic
• 2022 – 2024 Hosting Professor, Heidelberg University, Heidelberg, Germany (one of the three best universities in Germany, 42nd position according to World University Rankings 2022); Radiation Biophysics, Chromatin Architecture, etc.
• Joint Program Advisory Committee of the Institute of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Rep.
Teaching Courses (Masaryk University Brno. Czech Republic)
• F8270 Radiation Biophysics (2 h/w), Masaryk University, Faculty of Sciences, Brno (from 2007),
• C9041 Structure and function of eukaryotic chromosomes (2 h/w), Masaryk University, Faculty of Sciences, Brno (2016-17; 2017-18; 2018-19)
• XD100 Dissertation thesis supervision, Masaryk University, Faculty of Sciences, Brno
• Bi3061 Practicum from General Genetics (2 h/w), Masaryk University, Faculty of Sciences, Brno, 2000-2001
• Radiation Biophysics I (4 h/w), Heidelberg University, Kirchhoff Institute for Physics, Heidelberg, Germany (2022-2024)
• Radiation Biophysics II (2 h/w), Heidelberg University, Kirchhoff Institute for Physics, Heidelberg, Germany (2022-2024)
• Selected Topics of Radiation Biophysics (2 h/w), Heidelberg University, Kirchhoff Institute for Physics, Heidelberg, Germany (2022-2024)
• Spezielle Probleme der experimentalien Biophysik (2 h/w), Heidelberg University, Kirchhoff Institute for Physics, Heidelberg, Germany (2022-2024)
• Mikroskopie auf der Nanoskala und ihre Anwendungen (2 h/w), Heidelberg University, Kirchhoff Institute for Physics, Heidelberg, Germany (2022-2024)
• Biophysics of the Genome (2 h/w), Heidelberg University, Kirchhoff Institute for Physics, Heidelberg, Germany (2022-2024)
• Research Seminar (2 h/w), Heidelberg University, Kirchhoff Institute for Physics, Heidelberg, Germany (2022-2024)
• Journal Club (2 h/w), Heidelberg University, Kirchhoff Institute for Physics, Heidelberg, Germany (2022-2024)
Vybrané publikace
Impaktované časopisy
• Condensed Matter Systems Exposed to Radiation: Multiscale Theory, Simulations, and Experiment. Erenpreisa J, Giuliani A, Yoshikawa K, Falk M, Hildenbrand G, Salmina K, Freivalds T, Vainshelbaum N, Weidner J, Sievers A, Pilarczyk G, Hausmann M. Chem Rev. 2024;124(13):8014-8129. doi: 10.1021/acs.chemrev.3c00902. IF = 51.5 (Q1).
• Falk, M., et al. Chromatin structure influences the sensitivity of DNA to γ-radiation. BBA MCR, 2008, 1783(12), 2398-2414. IF = 6.090 (Q1 at the publishing date), cited 157 times
• Falk, M. et al. (Falk, M. corresp. au.). Higher-order chromatin structure in DSB induction, repair and misrepair. MutationResearch – Reviews in Mutation Research, 2010, 704(1-3), 88-100. IF = 8.741 (Q1), cited 111 times
• Falk, M. et al. (Falk, M. corresp. au.). Chromatin dynamics during DSB repair. BBA MCR, 2007, 1773(10), 1534-1545. IF = 6.090 (Q1 at the publishing date), cited 109 times
• Kozubek S. et al. 2002. 3D Structure of the Human Genome: Order in Randomness, Chromosoma 111/5: 321-331 (IF = 3.442, Q1), cited 102 times.
• Erenpreisa J, Giuliani A, Yoshikawa K, Falk M, Hildenbrand G, Salmina K, Freivalds T, Vainshelbaum N, Weidner J, Sievers A, Pilarczyk G, and Hausmann M. Spatial-temporal genome regulation in stress-response and cell-fate change. IJMS 2023, 24(3):2658; https://doi.org/10.3390/ijms24032658 (IF 6.208 / Q1).
• Dobešová L, Gier T, Kopečná O, Pagáčová E, Vičar T, Bestvater F, Toufar J, Bačíková A, Kopel P, Fedr R, Hildenbrand G, Falková I, Falk M (corresp. au.), and Hausmann M (corresp. au.). Incorporation of Low Concentrations of Gold Nanoparticles: Complex Effects on Radiation Response and Fate of Cancer Cells. Pharmaceutics 2022, 14(1), 166; https://doi.org/10.3390/pharmaceutics14010166., IF = 6.525 (Q1), cited 9 times
• Vicar T, Gumulec J, Kolar R, Kopecna O, Pagacova E, Falkova I, Falk M (corresp. au.). DeepFoci: Deep learning-based algorithm for fast automatic analysis of DNA double-strand break ionizing radiation-induced foci. Comput Struct Biotechnol J. 2021;19:6465-6480. doi:10.1016/j.csbj.2021.11.019. eCollection 2021. IF = 7.271 (Q1), cited 13 times
• Hahn H. et al. Topological Analysis of γH2AX and MRE11 Clusters Detected by Localization Microscopy during X-ray-Induced DNA Double-Strand Break Repair. Cancers, 2021, 13(21), 5561. IF = 6.639 (Q1), cited 11 times
• Falk M, Hausmann M. A paradigm revolution or just better resolution—will newly emerging superresolution techniques identify chromatin architecture as a key factor in radiation-induced dna damage and repair regulation? Cancers, 2021, 13 (1), 1-30, article no. 18. IF = 6.639 (Q1), cited 26 times
• Pagacova E et al. Challenges and contradictions of metal nano-particle applications for radio-sensitivity enhancement in cancer therapy. IJMS, 2019, 20/31, article 588. IF= 6.208 (Q1), cited 36 times
• Jezkova, L., et al. (Falk, M. corresp. au.). Particles with similar LET values generate DNA breaks of different complexity and reparability: A high-resolution microscopy analysis of γh2AX/53BP1 foci. Nanoscale, 2018, 10 (3), 1162-1179. IF = 8.307 (Q1), cited 62 times, nomin. for ČLS JEP 2019 Award
• Falk M et al. (Falk, M. corresp. au.). Chromatin architecture changes and DNA replication fork collapse are critical features in cryopreserved cells that are differentially controlled by cryoprotectants. Scientific Reports (Nature) 2018, 8(1), 14694. IF= 4.996 (Q1), cited 28 times
• Kratochvílová, I., Golan, M., Pomeisl, K., Richter, J., Sedláková, S., Šebera, J., Mičová, J., Falk, M., Falková, I., Řeha, D., Elliott, K. W., Varga, K., Follett, S. E., & Šimek, D. (2017). Theoretical and experimental study of the antifreeze protein AFP752, trehalose and dimethyl sulfoxide cryoprotection mechanism: correlation with cryopreserved cell viability. RSC Advances, 7(1), 352-360. IF = 3.9 (Q1), cited 50 times
• Hofer, M., Falk M, et al. (Falk, M. corresp. au.). Two new faces of amifostine: protector from DNA damage in normal cells and inhibitor of DNA repair in cancer cells. Journal of Medicinal Chemistry, 2016, 59(7), 3003-3017. IF = 8.039 (Q1), cited 60 times
• Lukasova E et al. Loss of lamin B receptor is necessary to induce cellular senescence. Biochemical Journal, 2017, 474/2:281-300. IF= 4.097 (Q1 at the publishing date), cited 57 times
• Stefancikova L et al. (Falk, M. corresp. au.) Effect of Gadolinium-based nanoparticles on nuclear DNA damage and repair in glioblastoma tumor cells. J Nanobiotechnol. 2016;14(1):63. IF= 10.435 (Q1) cited 53 times
KNIHY
• Falk M, Lukasova E, Kozubek S. Repair mechanisms of DNA double-strand breaks – Biochemical and Spatio-Temporal Aspects. In: Radiation Damage in Biomolecular Systems, Springer Science+Business Media (Eds.: G García, M Fuss), Dordrecht, Heidelberg, London, New York, 2012, p:329-359, ISSN 1618-7210, ISBN 978-94-007-2563-8, e-ISBN 978-94-007-2564-5, DOI 10.1007/978-94-007-2564-5_20.
• Falk M. 2012. Book of Proceedings by the American Institute of Physics [AIP]
• Štěpka K., and Falk M. 2014. ‘Image Analysis of Gene Locus Positions within Chromosome Territories in Human Lymphocytes’. In: Lecture Notes in Computer Science (LNCS), 125–34. 8934. Springer International Publishing
• Falk M., Falková I. The Cell – The Basic Unit of Life (Buňka – základní jednotka života). In: Clinical Radiobiology (Klinická radiobiologie). GRADA, Published 14. 01. 2020, catalog no.: 19052, ISBN: 978-80-247-4098-0. [in Czech]
• Falk M., Falková I. Ionizing Radiation Effects at the Subcellular and Cellular Level, DNA Repair Mechanisms (Účinky ionizujícího záření na subcelulární a celulární úrovni, mechanizmy reparace DNA). In: Clinical Radiobiology (Klinická radiobiologie). GRADA, Published 14. 01. 2020, catalog no.: 19052, ISBN: 978-80-247-4098-0. [in Czech]
• Falk M, Wolinsky M, Veldwijk MR, Hildenbrand G and Hausmann M. Gold nanoparticle enhanced radiosensitivity of cells: considerations and contradictions from model systems and basic investigations of cell damaging for radiation therapy. In Nanoparticle Enhanced Radiation Therapy Principles, methods and applications, 2020, Erno Sajo and Piotr Zygmanski (eds.), IOP Publishing Ltd
• Montoro, A. et al. (2023). Radioprotectors, Radiomitigators, and Radiosensitizers. In: Baatout, S. (eds) Radiobiology Textbook. Springer, Cham. https://doi.org/10.1007/978-3-031-18810-7_11
• Reindl, J. et al. (2023). Molecular Radiation Biology. In: Baatout, S. (eds) Radiobiology Textbook. Springer, Cham. https://doi.org/10.1007/978-3-031-18810-7_3
Ostatní
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